INPHYNI seminar: Lou Boulant--

  • Science and society
Published on October 2, 2026 – Updated on November 9, 2026
Dates

on the December 15, 2026

Café : 15h
Séminaire: 15h15
Location
Salle des séminaires

Fibrin matrices dissolution enhanced by self-assembling microswimmers: toward an improved ischemic strokes treatment (Lou Boulant) --

Seminars of the Institut de Physique de Nice, PhD Series

Abstract:

Lou Boulant - Fibrin matrices dissolution enhanced by self-assembling microswimmers: toward an improved ischemic strokes treatment

Ischemic stroke results from the obstruction of cerebral blood vessels by a clot, requiring rapid restoration of blood flow to limit severe aftereffects. However, thrombolysis is limited by the slow diffusion of thrombolytic drugs toward the clot. Here, we investigate self-assembled magnetic microswimmers to enhance drug transport. Under a weak rotating magnetic field, iron oxide nanoparticles assemble into micrometric aggregates whose collective motion generates a recirculating flow, convectively transporting the drug toward fibrin clots. In vitro microfluidic experiments demonstrate a nearly tenfold increase in fibrin-clot dissolution rate compared with passive diffusion, highlighting a promising strategy for accelerating thrombolytic treatment.